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the origins of depression: current concepts and approaches: report of the dahlem workshop on the origins of depression: current concepts and approache (in English)
J. Angst
(Other, Illustrated by)
·
S. a. Checkley
(Contributions by)
·
Springer
· Paperback
the origins of depression: current concepts and approaches: report of the dahlem workshop on the origins of depression: current concepts and approache (in English) - Angst, J. ; Angst, J. ; Checkley, S. a.
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Synopsis "the origins of depression: current concepts and approaches: report of the dahlem workshop on the origins of depression: current concepts and approache (in English)"
3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de- pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu- mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex- plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco- logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields.
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