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Study on in Vitro (in English)
Yuh-Tyng Huang (Author)
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· Paperback
Study on in Vitro (in English) - Yuh-Tyng Huang
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Origin: Spain
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Synopsis "Study on in Vitro (in English)"
Pyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. The PB sustained-release (SR) dosage forms that were developed by extrusion-spheronization, direct compression and fluid-bed methods. Produced by the aforementioned methods, the optimal PB-SR dosage forms could improve the hygroscopic defect of PB and reach the SR effect. In vivo study, a good linear regression relationship was observed between the fraction dissolution and fraction absorption for the optimal PB-SR dosage forms. However, the results of microdialysis technique shown that the release of acetylcholine and the release of protein unbound drug for the PB-SR pellets provided with SR effect in vivo as well.
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The book is written in English.
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