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portada Simultaneous Estimation of Cefixime and Linezolid (in English)
Type
Physical Book
Language
Inglés
Pages
88
Format
Paperback
Dimensions
22.9 x 15.2 x 0.5 cm
Weight
0.14 kg.
ISBN13
9786139454754
Categories

Simultaneous Estimation of Cefixime and Linezolid (in English)

Naisarg Pujara (Author) · Imran Chaki (Author) · Pratik Patel (Author) · LAP Lambert Academic Publishing · Paperback

Simultaneous Estimation of Cefixime and Linezolid (in English) - Chaki, Imran ; Patel, Pratik ; Pujara, Naisarg

Physical Book

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Synopsis "Simultaneous Estimation of Cefixime and Linezolid (in English)"

Development and validation of simple, precise, accurate, economical and sensitive HPLC assay method for the estimation of Cefixime and Linezolid in tablet dosage form. A chromatographic separation was achieved with a Hypersil BDS C18 (250mm,4.6mm,5 m) analytical column. A Mixture of Phosphate Buffer (3.0 pH): methanol (40:60, v/v) was used as the mobile phase, at a flow rate of 1.0 ml/min and detector wavelength at 277 nm. The retention time of Cefixime and linezolid was found to be 3.76 and 6.55 min respectively. Theoretical plates was 6896 and 4626 respectively and Tailing factor was 1.32 and 1.28. The linear ranges was 5-15 for cefixime and 15-45 μg/ml for linezolid, and the correlation coefficient was 0.999 for both drugs. The relative standard deviation was found to be less than 2%. A simple, precise, accurate, economical and sensitive HPLC assay method have been developed and validated for the estimation of Cefixime and linezolid in tablet dosage form. All method validation parameters lie within its acceptance crieteria as per ICH Q2(R1) guideline.

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The book is written in English.
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