Share
Selective Cox-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential (in English)
Vane, Sir John R. ; Botting, Jack H. (Author)
·
Springer
· Paperback
Selective Cox-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential (in English) - Vane, Sir John R. ; Botting, Jack H.
$ 104.20
$ 109.99
You save: $ 5.79
Choose the list to add your product or create one New List
✓ Product added successfully to the Wishlist.
Go to My WishlistsIt will be shipped from our warehouse between
Friday, July 05 and
Monday, July 08.
You will receive it anywhere in United States between 1 and 3 business days after shipment.
Synopsis "Selective Cox-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential (in English)"
The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result- ing from inhibition of the constitutive enzyme.
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
All books in our catalog are Original.
The book is written in English.
The binding of this edition is Paperback.
✓ Producto agregado correctamente al carro, Ir a Pagar.
