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portada Protein nmr Spectroscopy
Type
Physical Book
Publisher
Language
English
Pages
351
Format
Hardcover
ISBN
470721936
ISBN13
9780470721933
Edition No.
1
Categories

Protein nmr Spectroscopy

Lu-Yun (Edt) Lian,Gordon (Edt) Roberts (Author) · Wiley · Hardcover

Protein nmr Spectroscopy - lu-yun (edt) lian,gordon (edt) roberts

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Synopsis "Protein nmr Spectroscopy"

Nuclear Magnetic Resonance (NMR) spectroscopy, a physicalphenomenon based upon the magnetic properties of certain atomicnuclei, has found a wide range of applications in life sciencesover recent decades. The dramatic advances in NMR techniques haveled to corresponding advances in the ability of NMR to studystructure, dynamics and interactions of biological macromoleculesin solution under close to physiological conditions. This volumefocuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensionalstructures of proteins in solution. Furthermore, it providesinformation about conformational or chemical exchange, internalmobility and dynamics at timescales varying from pcoseconds toseconds. It is the primary technique used to obtain information onintrinsically disordered (unfolded) proteins, since these proteinswill not crystallize easily. NMR is also a very powerful method forthe study of interactions of protein with other molecules, whethersmall molecules (including drugs), nuclear acids or otherproteins.This up-to-date volume covers NMR techiniques and theirapplication to proteins, with a focus on practical details. Thisbook will provide a newcomer to NMR with the practical guidance inorder to carry out successful experiments with proteins and toanalyze the resulting spectra. Those who are familiar with thechemical applications of NMR will also find is useful inunderstanding the special requirements of protien NMR.

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