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peptidomimetics protocols (in English)
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Synopsis "peptidomimetics protocols (in English)"
a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. synthetic protocols towards the transition-state mimics and reactive warheads, applicable in enzyme inhibitors, are also disclosed.
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The book is written in English.
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