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portada Nanoparticles With the Aggregation-Induced Emission Effect: Properties and Applications: Photosensitizers for Photodynamic Therapy (in English)
Type
Physical Book
Publisher
Author
Language
English
Format
Paperback
ISBN13
9786200499141

Nanoparticles With the Aggregation-Induced Emission Effect: Properties and Applications: Photosensitizers for Photodynamic Therapy (in English)

Korotkova, Irina Und Tamara Sakhno: (Author) · Lap Lambert Academic Publishing · Paperback

Nanoparticles With the Aggregation-Induced Emission Effect: Properties and Applications: Photosensitizers for Photodynamic Therapy (in English) - Korotkova, Irina Und Tamara Sakhno:

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Synopsis "Nanoparticles With the Aggregation-Induced Emission Effect: Properties and Applications: Photosensitizers for Photodynamic Therapy (in English)"

Photodynamic therapy (PDT) is a method of the treatment of localized cancers, based on a photochemical reaction between a light-activated molecule or photosensitizer (PS), light, and molecular oxygen. Correct choice of PS is of fundamental importance for PDT efficacy. Despite numerous studies in this field, most known PS have some drawbacks, e.g. lack of specificity and aggregation in aqueous media. Consequently, the search for an ideal PS is essential for further development of PDT. Here we review classification and analyze main featuresof different generations of PS and describe the mechanisms of their action. Various methods of targeted delivery of PS to tumor cells are discussed. The advantages of PS nanoparticles with the effect of aggregation-induced emission (AIE) over the classic photosensitizers are presented. A possibility of practical application of such light-emitting structures in cancer phototherapy is shown.

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