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portada molecular aspects of oxidative drug metabolizing enzymes: their significance in environmental toxicology, chemical carcinogenesis and health (in English)
Type
Physical Book
Illustrated by
Publisher
Author
Year
2011
Language
Inglés
Pages
614
Format
Paperback
Dimensions
23.4 x 15.6 x 3.3 cm
Weight
0.88 kg.
ISBN
3642795307
ISBN13
9783642795305
Categories

molecular aspects of oxidative drug metabolizing enzymes: their significance in environmental toxicology, chemical carcinogenesis and health (in English)

Emel Arinc (Illustrated by) · John B. Schenkman (Illustrated by) · Ernest Hodgson (Illustrated by) · Springer · Paperback

molecular aspects of oxidative drug metabolizing enzymes: their significance in environmental toxicology, chemical carcinogenesis and health (in English) - Arinc, Emel ; Schenkman, John B. ; Hodgson, Ernest

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Synopsis "molecular aspects of oxidative drug metabolizing enzymes: their significance in environmental toxicology, chemical carcinogenesis and health (in English)"

Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.

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