Origin: United Kingdom
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gene-environment interactions: fundamentals of ecogenetics
lucio g. costa, david l. eaton
Synopsis "gene-environment interactions: fundamentals of ecogenetics"
this book covers basic and applied concepts of ecogenetics. the book is organized into four sections. the first section covers fundamental aspects of ecogenetics, such as history of the discipline, a discussion of the molecular tools currently available to assess genotypes and their pros and cons, the use of such measurements in molecular epidemiology studies, and considerations on how knowledge acquired in pharmacogenetics can be applied to ecogenetics. the second section discusses key genetic polymorphisms relevant for ecogenetics. these chapters discuss the characteristics of known polymorphisms and how they influence the response to environmental chemicals. in the third section, ecogenetics is presented on a disease-based approach, to address the question of how genetic polymorphisms can influence gene-environment interactions relevant to determining susceptibility to the disease. these core chapters address various types of cancers (lung, breast, hematopoietic, gastrointestinal), neurodegenerative diseases, cardiovascular disease, diabetes, and obesity.
