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Formulation Evaluation of Bilayer Tablet of Saxagliptin & Repaglinide (in English)
Priyanka Yadav
(Author)
·
Anjali Soni
(Author)
·
Dharmendra Solanki
(Author)
·
LAP Lambert Academic Publishing
· Paperback
Formulation Evaluation of Bilayer Tablet of Saxagliptin & Repaglinide (in English) - Soni, Anjali ; Solanki, Dharmendra ; Yadav, Priyanka
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Synopsis "Formulation Evaluation of Bilayer Tablet of Saxagliptin & Repaglinide (in English)"
In the present research work, an attempt has been made to optimize and formulate bilayer tablet of saxagliptin and repaglinide to achieve immediate release of saxagliptin and sustained release of repaglinide.Saxagliptin is DPP-4 inhibitor and belonging to BCS class 1 (high solubility, high permeability). It has long half life, so an attempt was made to achieve its fast action by making immediate release tablet by using superdisintegrant sodium starch glycolate..Repaglinide is an oral blood glucose-lowering drug of the maglitinide class used in the management of type 2 diabetes mellitus. It is absorbed by oral route and has short half life, so an attempt has been done to make sustained release tablet of repaglinide And it was concluded that the optimized formula RG4 (75 mg) drug (98.6 %) in 12 hrs. So by taking both optimized formulation in fixed dose combination in different layer. A bilayer tablet was prepared with 50 mg saxagliptin and 500 mg of repaglinide.
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